| Identification | More | [Name]
m-Toluidine | [CAS]
108-44-1 | [Synonyms]
3-AMINO-1-METHYLBENZENE
3-AMINOTOLUENE
3-METHYLALANINE
3-METHYLANILINE
3-METHYLBENZENAMINE
3-Toluidine
AKOS BBS-00003559
META TOLUIDINE
m-Toluamine
M-TOLUIDINE
m-Tolylamine
1-Amino-3-methylbenzene
3-Aminophenylmethane
3-Aminotoluen
3-aminotoluen(czech)
3-methyl-anilin
3-methyl-benzenamin
Aniline, 3-methyl-
aniline,3-methyl-
Benzenamine,3-methyl- | [EINECS(EC#)]
203-583-1 | [Molecular Formula]
C7H9N | [MDL Number]
MFCD00007808 | [Molecular Weight]
107.15 | [MOL File]
108-44-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid. Slightly soluble
in water; soluble in alcohol or ether. Combustible. | [Melting point ]
-30 °C
| [Boiling point ]
203-204 °C(lit.)
| [density ]
0.999 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.3 hPa (20 °C) | [refractive index ]
n20/D 1.567(lit.)
| [Fp ]
186 °F
| [storage temp. ]
Refrigerator | [solubility ]
0.2 g/100 mL (20°C) | [form ]
Crystalline Solid or Liquid | [pka]
4.73(at 25℃) | [color ]
White | [Odor]
aromatic aniline-like odor | [PH]
7 (H2O, 20℃) | [Water Solubility ]
0.2 g/100 mL (20 ºC) | [Merck ]
14,9536 | [BRN ]
635944 | [Dielectric constant]
5.9500000000000002 | [Exposure limits]
TLV-TWA skin 2-ppm (～9 mg/m3) (ACGIH). | [InChIKey]
JJYPMNFTHPTTDI-UHFFFAOYSA-N | [LogP]
1.4 at 25℃ | [Uses]
Dyes, manufacture of organic chemicals. | [CAS DataBase Reference]
108-44-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 3-methyl-(108-44-1) | [Storage Precautions]
Air sensitive;Store under nitrogen;Moisture sensitive | [EPA Substance Registry System]
108-44-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
R45:May cause cancer.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R50:Very Toxic to aquatic organisms. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 1708 6.1/PG 2
| [WGK Germany ]
2
| [RTECS ]
XU2800000
| [F ]
8-23 | [Autoignition Temperature]
>500 °C | [Hazard Note ]
Toxic | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29171990 | [HS Code ]
29214300 | [Safety Profile]
Poison by ingestion and
intraperitoneal routes, A skin and eye
irritant. Flammable when exposed to heat or
flame. Can react vigorously on contact with
oxidizing materials. To fight fire, use foam,
CO2, dry chemical. When heated to
decomposition it emits hghly toxic fumes of
NOx. See also ANILINE and o-TOLUIDINE. | [Hazardous Substances Data]
108-44-1(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A clear colorless liquid. Flash point below 200°F. Vapors heavier than air. Toxic by inhalation, ingestion, and skin absorption in high concentrations or under prolonged exposures. Used in the manufacture of organic chemicals. Density about 8 lb/gal. | [Reactivity Profile]
M-TOLUIDINE(108-44-1) neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Can react vigorously with oxidizing reagents. Emits toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1253]. | [Air & Water Reactions]
Slightly soluble in water. | [Health Hazard]
Absorption of toxic quantities by any route causes cyanosis (blue discoloroation of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation. | [Fire Hazard]
Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire. | [Chemical Properties]
Colorless liquid. Slightly soluble
in water; soluble in alcohol or ether. Combustible. | [Synthesis Reference(s)]
Synthetic Communications, 11, p. 925, 1981 DOI: 10.1080/00397918108065749 | [Flammability and Explosibility]
Nonflammable | [Carcinogenicity]
In an 18-month carcinogenicity diet evaluation in maleCD
rats (8000 ppm for 3 months, and then 4000 ppm for additional
15 months; or 16,000 ppm for 3 months, and then 8000
for additional 15 months), and male and female CD-1 mice
(16,000 ppm for 5 months, and then 4000 ppm in males and
8000 ppm in females for additional 13 months; or
32,000 ppm in both sexes for 5 months, and then
8000 ppm in males and 16,000 ppm in females for additional
13 months), there was no evidence of a significant increase of
incidence of any kind of tumor in the rats, and only a
significant increase in liver tumors in male mice. | [Purification Methods]
It can be purified as for aniline. Twice-distilled, m-toluidine is converted to the hydrochloride using a slight excess of HCl, and the salt is fractionally crystallised from 25% EtOH (five times), and from distilled water (twice), rejecting, in each case, the first material that crystallised out. The amine is regenerated and distilled as for o-toluidine. The benzoyl derivative has m 125o (from EtOH). [Berliner & May J Am Chem Soc 49 1007 1927, Beilstein 12 H 853, 12 I 397, 12 II 463, 12 III 1949, 12 IV 1813.] |
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