| Identification | More | [Name]
m-Xylene | [CAS]
108-38-3 | [Synonyms]
1,3-DIMETHYLBENZENE
1，3-Xylene
META-XYLENE
M-METHYLTOLUENE
M-XYLENE
[srp]m-methyltoluene
1,3-dimethyl-benzen
2,4-Xylene
3-methyltoluene
3-xylene
ai3-08916
Benzene,1,3-dimethyl-
m-Dimethylbenzene
m-Xylol
META XYLEN
M-XYLENE OEKANAL
M-XYLENE, REAGENTPLUS, 99%
M-XYLENE, 1X1ML, MEOH, 200UG/ML
M-XYLENE, STANDARD FOR GC
M-XYLENE DISTILLED 1 L | [EINECS(EC#)]
203-576-3 | [Molecular Formula]
C8H10 | [MDL Number]
MFCD00008536 | [Molecular Weight]
106.17 | [MOL File]
108-38-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Xylene exists in three isomeric forms, ortho-,
meta-, and para-xylene. Commercial xylene is a mixture of
these three isomers and may also contain ethylbenzene as
well as small amounts of toluene, trimethylbenzene, phenol,
thiophene, pyridine, and other nonaromatic hydrocarbons.
m-Xylene is predominant in commercial xylene. | [Melting point ]
-48 °C (lit.) | [Boiling point ]
138-139 °C (lit.) | [density ]
0.868 g/mL at 25 °C(lit.)
| [vapor density ]
3.7 (vs air)
| [vapor pressure ]
16 mm Hg ( 37.7 °C)
| [refractive index ]
n20/D 1.497(lit.)
| [Fp ]
77 °F
| [storage temp. ]
0-6°C
| [solubility ]
Miscible with many organic solvents, including alcohol and ether | [form ]
Liquid | [pka]
>15 (Christensen et al., 1975) | [color ]
Colorless | [Odor]
Like benzene; characteristic aromatic. | [explosive limit]
1.1-7%(V) | [Odor Threshold]
0.041ppm | [Water Solubility ]
Miscible with organic solvents. Immiscible with water. | [Usage]
Meta-Xylene is used for the production of isophthalic acid, of agriculture chemicals as pharmaceuticals. It finds applications in paint and varnish removers and aerosol paint concentrates. Product Data Sheet | [Merck ]
14,10081 | [BRN ]
605441 | [Henry's Law Constant]
14.80 at 45.00 °C, 17.26.4 at 50.00 °C, 19.90 at 55.00 °C, 23.01.3 at 60.00 °C, 27.46.3 at 70.00 °C
(static headspace-GC, Park et al., 2004) | [Dielectric constant]
2.3999999999999999 | [Exposure limits]
NIOSH REL: 100 ppm (435 mg/m3), STEL 150 ppm (655 mg/m3), IDLH 900
ppm; OSHA PEL: TWA 100 ppm; ACGIH TLV: TWA 100 ppm, STEL 150 ppm (adopted). | [InChIKey]
IVSZLXZYQVIEFR-UHFFFAOYSA-N | [LogP]
3.16 at 20℃ | [CAS DataBase Reference]
108-38-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, 1,3-dimethyl-(108-38-3) | [EPA Substance Registry System]
108-38-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,F | [Risk Statements ]
R10:Flammable.
R20/21:Harmful by inhalation and in contact with skin .
R38:Irritating to the skin.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S25:Avoid contact with eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed . | [RIDADR ]
UN 1307 3/PG 3
| [WGK Germany ]
2
| [RTECS ]
ZE2275000
| [Autoignition Temperature]
982 °F | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29024200 | [Safety Profile]
Moderately toxic by
intraperitoneal route. Wdly toxic by
ingestion, skin contact, and inhalation. An
experimental teratogen. Human systemic
effects by inhalation: motor activity changes,
ataxia, and irritabihty. Experimental
reproductive effects. A severe skin irritant.
A common air contaminant. A very
dangerous fire hazard when exposed to heat
or flame; can react with oxidzing materials.
Explosive in the form of vapor when
exposed to heat or flame. To fight fire, use
foam, CO2, dry chemical. Emitted from
modern building materials (CENEAR
69,22,91). When heated to decomposition it
emits acrid smoke and irritating fumes. See
also other xylene entries. | [Hazardous Substances Data]
108-38-3(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 7.71 ml/kg (Smyth) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Hydrogen-->Xylene-->P-XYLENE-->COAL TAR-->Y type molecular sieve-->Adsorbent | [Preparation Products]
P-XYLENE-->o-Xylene-->2,6-Dimethylaniline-->Metalaxyl-->Isophthalic acid-->Amitraz-->4-BROMO-3-METHYLBENZAMIDE-->Chlorothalonil-->Pyromellitic Dianhydride-->1,2,4,5-Tetramethylbenzene-->1,3-Dicyanobenzene-->m-Toluic acid-->2,4-Dimethyl aniline-->Musk xylene-->AMITRAZ METABOLITE HYDROCHLORIDE-->4-TERT-BUTYL-2,6-DIMETHYL BENZYL ACETATE-->1,4-BIS(TRICHLOROMETHYL)BENZENE-->2-(Dimethylamino)ethyl (4-chlorphenoxy)acetate-->Musk ketone-->4-Nitro-1,3-dimethylbenzene-->1-tert-Butyl-3,5-dimethylbenzene-->2,6-Dicyano-4-Nitroaniline-->2,6-Dimethyl-1-nitrobenzene-->3,5-Dimethylphenol-->4-TERT-BUTYL-3-HYDROXY-2,6-DIMETHYLPHENYLACETONITRILE-->Diphenyl isophthalate-->4-Tert-butyl-2,6-dimethylbenzylchloroide-->2',4'-Dimethylacetophenone-->1,3-Bis(trifluoromethyl)-benzene-->ISOCYANATO(METHOXY)METHANE-->3-Methylbenzyl chloride-->2,4-Dimethylphenol |
| Hazard Information | Back Directory | [General Description]
A colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. | [Reactivity Profile]
M-XYLENE(108-38-3) may react with oxidizing materials. . | [Air & Water Reactions]
Highly flammable. Insoluble in water. | [Health Hazard]
Vapors cause headache and dizziness. Liquid irritates eyes and skin. If taken into lungs, causes severe coughing, distress, and rapidly developing pulmonary edema. If ingested, causes nausea, vomiting, cramps, headache, and coma; can be fatal. Kidney and liver damage can occur. | [Potential Exposure]
Xylene is used as a solvent; as a constituent
of paint, lacquers, varnishes, inks, dyes, adhesives,
cements, cleaning fluids, and aviation fuels; and as a chemical
feed-stock for xylidines, benzoic acid; phthalic anhydride;
isophthalic, and terephthalic acids; as well as their
esters (which are specifically used in the manufacture
of plastic materials and synthetic textile fabrics). Xylene
is also used in the manufacture of quartz crystal oscillators,
hydrogen peroxide; perfumes, insect repellants; epoxy
resins; pharmaceuticals; and in the leather industry.
m-Xylene is used as an intermediate in preparation of isophthalic
acid; o-xylene is used in manufacture of phthalic
anhydride and in pharmaceutical and insecticide synthesis.
p-xylene is used in pharmaceutical and insecticide synthesis
and in production of polyester. | [Fire Hazard]
Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. If victim is conscious, administer water, or milk.
Do not induce vomiting. Medical observation is recommended
for 24 to 48 hours after breathing overexposure, as
pulmonary edema may be delayed. As first aid for pulmonary
edema, a qualified medical professional might
consider administering a corticosteroid spray. Cigarette
smoking may exacerbate pulmonary injury and should be
discouraged for at least 72 hours following exposure. If
symptoms develop or overexposure is suspected, chest X-ray
should be considered. | [Shipping]
UN1307 Xylenes, Hazard Class: 3; Labels:
3-Flammable liquid. | [Incompatibilities]
Vapor may form explosive mixture
with air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, and epoxides. Electrostatic charges can be
generated from agitation or flow. | [Description]
Xylene exists in three isomeric forms, ortho-,meta-, and para-xylene. Commercial xylene is a mixture ofthese three isomers and may also contain ethylbenzene aswell as small amounts of toluene, trimethylbenzene, phenol,thiophene, pyridine, and other nonaromatic hydrocarbons.m-Xylene is predominant in commercial xylene. The physical properties of the three isomers are as follows:Isomer MeltingPoint(℃)BoilingPoint(℃)FlashPoint(℃)LowerExpl.(%)UpperExpl.(%)AutoTemp.(℃)ortho- -25 144 32 0.9 6.7 463meta- -48 139 27 1.1 7.0 527para- 13 138 27 1.1 7.0 528 | [Chemical Properties]
clear colourless liquid | [Chemical Properties]
Xylene exists in three isomeric forms, ortho-,
meta-, and para-xylene. Commercial xylene is a mixture of
these three isomers and may also contain ethylbenzene as
well as small amounts of toluene, trimethylbenzene, phenol,
thiophene, pyridine, and other nonaromatic hydrocarbons.
m-Xylene is predominant in commercial xylene. | [Waste Disposal]
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Incineration. | [Physical properties]
Clear, colorless, watery liquid with a sweet, aromatic odor. An odor threshold concentration of 48
ppbv was reported by Nagata and Takeuchi (1990). | [Uses]
Meta-Xylene is used for the production of isophthalic acid, of agriculture chemicals as pharmaceuticals. It finds applications in paint and varnish removers and aerosol paint concentrates. Product Data Sheet | [Definition]
ChEBI: A xylene carrying methyl groups at positions 1 and 3. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 79, p. 2910, 1957 DOI: 10.1021/ja01568a059 | [Flammability and Explosibility]
Flammable | [Chemical Reactivity]
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Source]
As m+p-xylene, detected in distilled water-soluble fractions of 87 octane gasoline, 94
octane gasoline, and Gasohol at concentrations of 7.00, 20.1, and 14.6 mg/L, respectively (Potter,
1996); in distilled water-soluble fractions of new and used motor oil at concentrations of 0.26 to
0.29 and 302 to 339 μg/L, respectively (Chen et al., 1994). The average volume percent and
estimated mole fraction in American Petroleum Institute PS-6 gasoline are 4.072 and 0.04406,
respectively (Poulsen et al., 1992). Diesel fuel obtained from a service station in Schlieren,
Switzerland contained m/p-xylene at a concentration of 336 mg/L (Schluep et al., 2001).
Thomas and Delfino (1991) equilibrated contaminant-free groundwater collected from
Gainesville, FL with individual fractions of three individual petroleum products at 24–25 °C for
24 h. The aqueous phase was analyzed for organic compounds via U.S. EPA approved test method
602. Average m+p-xylene concentrations reported in water-soluble fractions of unleaded gasoline,
kerosene, and diesel fuel were 8.611, 0.658, and 0.228 mg/L, respectively. When the authors
analyzed the aqueous-phase via U.S. EPA approved test method 610, average m+p-xylene
concentrations in water-soluble fractions of unleaded gasoline, kerosene, and diesel fuel were
lower, i.e., 6.068, 0.360, and 0.222 mg/L, respectively.
Based on laboratory analysis of 7 coal tar samples, m+p-xylene concentrations ranged from ND
to 6,000 ppm (EPRI, 1990). A high-temperature coal tar contained m-xylene at an average
concentration of 0.07 wt % (McNeil, 1983).
Schauer et al. (2001) measured organic compound emission rates for volatile organic
compounds, gas-phase semi-volatile organic compounds, and particle-phase organic compounds
from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission
rate of m-xylene + p-xylene was 60.0 mg/kg of pine burned. Emission rates of both isomers were
not measured during the combustion of oak and eucalyptus.
Drinking water standard (final): For all xylenes, the MCLG and MCL are both 10 mg/L. In
addition, a DWEL of 70 mg/L was recommended (U.S. EPA, 2000). | [Environmental Fate]
Biological. Microbial degradation produced 3-methylbenzyl alcohol, 3-methylbenzaldehyde, mtoluic
acid, and 3-methylcatechol (quoted, Verschueren, 1983). m-Toluic acid was reported to be
the biooxidation product of m-xylene by Nocardia corallina V-49 using n-hexadecane as the
substrate (Keck et al., 1989). Reported biodegradation products of the commercial product
containing xylene include α-hydroxy-p-toluic acid, p-methylbenzyl alcohol, benzyl alcohol, 4-
methylcatechol, m- and p-toluic acids (Fishbein, 1985). In anoxic groundwater near Bemidji, MI,
m-xylene anaerobically biodegraded to the intermediate m-toluic acid (Cozzarelli et al., 1990). In
gasoline-contaminated groundwater, methylbenzylsuccinic acid was identified as the first
intermediate during the anaerobic degradation of xylenes (Reusser and Field, 2002).
Photolytic. When synthetic air containing gaseous nitrous acid and m-xylene was exposed to
artificial sunlight (λ = 300–450 nm) biacetyl, peroxyacetal nitrate, and methyl nitrate were formed
(Cox et al., 1980). They reported a rate constant of 1.86 x 10-11 cm3/molecule?sec for the reaction
of gaseous m-xylene with OH radicals based on a value of 8 x 10-12 cm3/molecule?sec for the
reaction of ethylene with OH radicals.
Chemical/Physical. Under atmospheric conditions, the gas-phase reaction with OH radicals and
nitrogen oxides resulted in the formation of m-tolualdehyde, m-methylbenzyl nitrate, nitro- mxylenes,
2,4- and 2,6-dimethylphenol (Atkinson, 1990). Kanno et al. (1982) studied the aqueous
reaction of m-xylene and other aromatic hydrocarbons (benzene, toluene, o- and p-xylene, and
naphthalene) with hypochlorous acid in the presence of ammonium ion. They reported that the
aromatic ring was not chlorinated as expected but was cleaved by chloramine forming cyanogen
chloride. The amount of cyanogen chloride formed increased at lower pHs (Kanno et al., 1982). In
the gas phase, m-xylene reacted with nitrate radicals in purified air forming pmethylbenzaldehyde,
an aryl nitrate and trace amounts of 2,6-dimethylnitrobenzene, 2,4-
dimethylnitrobenzene, and 3,5-dimethylnitrobenzene (Chiodini et al., 1993). | [storage]
Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with this chemical you should be trainedon its proper handling and storage. Xylenes must be storedto avoid contact with strong oxidizers (such as chlorine,bromine, and fluorine) since violent reactions occur.Sources of ignition, such as smoking and open flames, areprohibited where xylenes are used, handled, or stored in amanner that could create a potential fire or explosionhazard. Use only nonsparking tools and equipment, especially when opening and closing containers of xylenes.Protect storage containers from physical damage. | [Purification Methods]
The general purification methods listed under xylene are applicable. The o-and p-isomers can be removed by their selective oxidation when a m-xylene sample containing them is boiled with dilute HNO3 (one part conc acid to three parts water). After washing with water and alkali, the product can be steam distilled, collected as for o-xylene, then distilled and purified further by sulfonation. [Clarke & Taylor J Am Chem Soc 45 831 1923.] m-Xylene is selectively sulfonated when a mixture of xylenes is refluxed with the theoretical amount of 50-70% H2SO4 at 85-95o under reduced pressure. By using a still resembling a Dean and Stark apparatus, water in the condensate can be progressively withdrawn while the xylene is returned to the reaction vessel. After cooling, then adding water, unreacted xylenes are distilled off under reduced pressure. The m-xylene sulfonic acid is subsequently hydrolysed by steam distillation up to 140o, the free m-xylene is washed, dried with silica gel and again distilled. It is stored over molecular sieves Linde type 4A. [Beilstein 5 H 370, 5 I 182, 5 II 287, 5 III 823, 5 IV 932.] |
|
|