| Identification | More | [Name]
Acethydrazide | [CAS]
1068-57-1 | [Synonyms]
ACETHYDRAZIDE
ACETIC ACID HYDRAZIDE
ACETIC HYDRAZIDE
ACETOHYDRAZIDE
ACETYLHYDRAZINE
AKOS 90782
MONOACETYLHYDRAZINE
N-ACETYL HYDRAZINE
374
Acetyl hydrazide
acetylhydrazide
acetyl-hydrazin
ENT-61241
Ethanehydrazonic acid
ethanehydrazonicacid
Hydrazid kyseliny octove
hydrazidkyselinyoctove
Hydrazine, Acetyl-
N-Acetyldiamine
NSC 53155 | [EINECS(EC#)]
213-948-7 | [Molecular Formula]
C2H6N2O | [MDL Number]
MFCD00007610 | [Molecular Weight]
74.08 | [MOL File]
1068-57-1.mol |
| Questions And Answer | Back Directory | [Description]
Acethydrazide is an essential organic intermediate mainly used to synthesize nifuratrone in the pharmaceutical industry. It belongs to the hydrazine/hydrazone group, which plays an important role in the anti-microbial activity. Recently, Acethydrazide has gained significant importance due to its anti-tuberculosis activity. A disease caused by parasites represents a major world health problem with limited therapeutic options. Acethydrazide was synthesized from the reaction between ethyl acetate and hydrazine hydrate in methanol solvent and purified[1-2].
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| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
1759 | [WGK Germany ]
1
| [RTECS ]
AI1225000
| [F ]
3-8-10 | [TSCA ]
Y | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29280090 | [Safety Profile]
Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,. | [Toxicity]
LD50 oral in bird - wild: 42200ug/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
2-N-BUTOXYETHYL METHACRYLATE-->Acetamide,N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)--->NSC45006-->2-butanone (1-methylpropylidene)hydrazone-->Hydrazinecarboxylic acid, 2-acetyl-, 1,1-dimethylethyl ester (9CI)-->3,6-Dithia-1,8-octanediol-->Ethyl acetimidate hydrochloride-->Dibenzoylmethane-->Benzoylacetone-->Acetamide | [Preparation Products]
2-Mercapto-5-methyl-1,3,4-thiadiazole-->5-Methyl-1,3,4-oxadiazol-2(3H)-one-->FlubroMazolaM-->2-Amino-5-methyl-1,3,4-thiadiazole-->Ethyl 5-Methyl-1,3,4-thiadiazole-2-carboxylate-->Methylamine nitrate-->5-METHYL-1,3,4-OXADIAZOL-2-YLAMINE-->(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
| Hazard Information | Back Directory | [Chemical Properties]
White moist crystals and chunks | [Uses]
Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. | [Definition]
ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group. | [Purification Methods]
Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.] |
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