| Identification | More | [Name]
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | [CAS]
10212-20-1 | [Synonyms]
2'-DEOXY-2'-FLUOROCYTIDINE
2'-FC
2'-FLUORO-2'-DEOXYCYTIDINE
2'-FLUORO-D-CYTIDINE
4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-AMINO-1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDIN-2-ONE
2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'-DEOXYCYTIDINE, 2'-FC)
2'-Deoxy-2'-fluoro-D-cytidine
2''-DEOXY-2''-FLUOROCYTIDINE,99+%
2'-Deoxy-2'-fluorocytidine Hydrate
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine
1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine
RO-8013
2'-FdC | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C9H12FN3O4 | [MDL Number]
MFCD00057445 | [Molecular Weight]
245.21 | [MOL File]
10212-20-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
167 °C | [Boiling point ]
500.1±60.0 °C(Predicted) | [density ]
1.82±0.1 g/cm3(Predicted) | [refractive index ]
80 ° (C=1, MeOH) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO, Methanol. | [form ]
Powder | [pka]
12.84±0.70(Predicted) | [color ]
White to Off-white | [Water Solubility ]
Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C) | [InChI]
InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1 | [InChIKey]
NVZFZMCNALTPBY-XVFCMESISA-N | [SMILES]
OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O | [CAS DataBase Reference]
10212-20-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [HS Code ]
29389090 |
| Hazard Information | Back Directory | [Description]
2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus. | [Chemical Properties]
White Solid | [Uses]
2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s
pread. | [in vitro]
2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.
| [References]
[1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.
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