天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Torezolid
856866-72-3

Torezolid synthesis

11synthesis methods
444335-16-4 Synthesis
(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE

444335-16-4
208 suppliers
$8.00/250mg

380380-64-3 Synthesis
5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE

380380-64-3
254 suppliers
$10.00/250mg

Torezolid

856866-72-3
254 suppliers
inquiry

-

Yield:856866-72-3 83%

Reaction Conditions:

Stage #1:(R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;potassium acetate;bis(pinacol)diborane in dimethyl sulfoxide at 80; for 14 h;Inert atmosphere;
Stage #2:5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;caesium carbonate in 1,4-dioxane;water at 70; for 3 h;Inert atmosphere;

Steps:

1 Example 1: Preparation of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (Formula V)
DMSO (100 ml) was added to a 250 ml reaction flask,(5R) -3- (4-bromo-3-fluorophenyl) -5-hydroxymethyloxazolidin-2-one(10 g, 34.5 mmol), pinacolate (17.52 g, 69 mmol),[1,1'-bis (diphenylphosphino) ferrocene] dichloropalladium dichloromethane complex (1.41 g, 1.73 mmol)And potassium acetate (13.5 g, 138 mmol), and the temperature was raised to 80 ° C under a nitrogen atmosphere,For 14 hours. The heating was stopped, the solution was cooled to room temperature, and extracted with water / ethyl acetate 3 times. The organic layers were combined and the organic layer was washed with saturated waterBrine, dried over anhydrous sodium sulfate and concentrated by suction filtration. The concentrated product of the above step was added to a 250 ml reaction flask,1,4-dioxane (100 ml) was added,5-bromo-2- (2-methyl-2H-tetrazol-5-yl) pyridine(8.28 g, 34.5 mmol),[1,1'-bis (diphenylphosphino) ferrocene] dichloropalladium dichloromethane complex (0.56 g, 0.69 mmol)And cesium carbonate aqueous solution (50 ml, containing 33.72 g of cesium carbonate, 103.5 mmol),Under nitrogen protection,The temperature was raised to 70 ° C,The reaction was carried out for 3 hours,Dichloromethane was added for extraction.The separated organic phase was washed with saturated brine,Anhydrous sodium sulfate dehydration,filter,Concentrated in vacuo and purified by column chromatography,10.6 g of a solid was obtained,The yield was 83.0%HPLC purity was 98.34% (area normalization method).

References:

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.;Zhu, Yizhong;Zhang, Xiquan;Liu, Fei;Gu, Hongmei;Zhu, Bo;Tang, Song;Wang, Lulu CN105418678, 2016, A Location in patent:Paragraph 0070; 0071; 0072; 0073; 0074; 0075

1220910-89-3 Synthesis
CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester

1220910-89-3
132 suppliers
inquiry

60456-26-0 Synthesis
(R)-Glycidyl butyrate

60456-26-0
306 suppliers
$14.14/1gm:

Torezolid

856866-72-3
254 suppliers
inquiry

1220910-89-3 Synthesis
CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester

1220910-89-3
132 suppliers
inquiry

Torezolid

856866-72-3
254 suppliers
inquiry

Torezolid Related Search: