ChemicalBook CAS DataBase List tert-Butyl 3-aminopyrrolidine-1-carboxylate

tert-Butyl 3-aminopyrrolidine-1-carboxylate synthesis

10synthesis methods

Product Name:tert-Butyl 3-aminopyrrolidine-1-carboxylate
CAS Number:186550-13-0
Molecular formula:C9H18N2O2
Molecular Weight:186.25

24424-99-5 Synthesis

24424-99-5
833 suppliers
$13.50/25G

79286-79-6
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$20.00/250mg

tert-Butyl 3-aminopyrrolidine-1-carboxylate

186550-13-0
223 suppliers
$8.00/1g

Yield:186550-13-0 98%

Reaction Conditions:

in chloroform at 20; for 1 h;

Steps:

A9 Example A9; 3RS- [4-AMINO-5- (2, 6-DIFLUORO-BENZOYL)-THIAZOL-2-YLAMINO]-PYRROLIDINE-1-CARBOXYLIC acid TERF-BUTYL ESTER
The starting materials were prepared as follows : 3RS-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TEFF-BUTYL ESTER To a solution of 3-aminopyrrolidine (0. 86 g, 10 MMOL) in CHCI3 (50 mi) at 0 C was added dropwise a solution of di-t-butyl dicarbonate ((BOC) 2O ; 2. 06 g, 10 MMOL) in CHCI3 (50 ML). The mixture stirred at room temperature for 1 hour, and then washed with brine, dried over K2CO3, filtered, and concentrated to give 1. 8 g of yellow oil in 98% yield, which was used without further purification. 'H NMR : 8 3. 60-3. 28 (m, 4H), 3. 02 (m, 1 H), 2. 04 (m, 1 H), 1. 64 (m, 1 H), 1. 45 (s, 9H), 1. 45-1. 20 (m, 2H)

References:

PFIZER INC. WO2004/74283, 2004, A1 Location in patent:Page 38

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