Siponimod synthesis
- Product Name:Siponimod
- CAS Number:1378888-43-7
- Molecular formula:C11H14O2
- Molecular Weight:178.23
1418144-63-4
7 suppliers
inquiry
1378888-43-7
103 suppliers
$20.00/100mg
Yield:1378888-43-7 89%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in ethanol at 20; for 3 h;
Steps:
1.4 1-[3-ethyl-4-(hydroxymethyl)phenyl]ethan-1-one
1-[3-ethyl-4-(hydroxymethyl)phenyl]ethan-1-one: To a solution of 1-[3-ethenyl- 4-(hydroxymethyl)phenyl]ethan-1-one (5 g, 28.41 mmol, 1.00 equiv.) in ethanol (20 mL), Palladium carbon (1 g) was added. The mixture was purged with H2. The mixture was stirred for 3 h at 20 oC. The reaction was monitored by LCMS. Then the solids were filtered out. The filtrate was concentrated to afford 4.5 g (89%) of 1-[3-ethyl-4- (hydroxymethyl)phenyl]ethan-1-one as white oil. LC-MS: m/z = 179 [M+H]+.
References:
WO2017/120124,2017,A1 Location in patent:Paragraph 00246
1418144-62-3
18 suppliers
inquiry
1378888-43-7
103 suppliers
$20.00/100mg
40180-80-1
188 suppliers
$23.00/1g
1378888-43-7
103 suppliers
$20.00/100mg
909190-70-1
27 suppliers
inquiry
1378888-43-7
103 suppliers
$20.00/100mg
578-54-1
254 suppliers
$10.00/5g
1378888-43-7
103 suppliers
$20.00/100mg