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ChemicalBook CAS DataBase List 2-Ethylaniline
578-54-1

2-Ethylaniline synthesis

13synthesis methods
-

Yield:578-54-1 90%

Reaction Conditions:

with iron in water at 20;Inert atmosphere;

Steps:

General experimental procedure for reduction of azidoarenes
General procedure: The azido compound (1 mmol) was added to the freshly prepared Fe(0) nanoparticles (3 mmol) in water (5 mL) in the same pot under constant stirring at room temperature under argon atmosphere. After completion of reaction (TLC) the mixture was extracted with ethyl acetate (3 X 10 mL) (all Fe-species remained around stirring bar). Evaporation of solvent and purification by short column chromatography provided the pure product which was properly characterized by spectroscopic (IR, 1H NMR and 13C NMR) data.

References:

Panja, Subir;kundu, Debasish;Ahammed, Sabir;Ranu, Brindaban C. [Tetrahedron Letters,2017,vol. 58,# 35,p. 3457 - 3460] Location in patent:supporting information

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