天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Rasagiline
136236-51-6

Rasagiline synthesis

10synthesis methods
-

Yield:136236-51-6 79%

Reaction Conditions:

with potassium carbonate in acetonitrile at 60; for 16 h;

Steps:

2.9. Synthesis of (R)-N-propargyl-1-aminoindan (R-6)
A suspension of (R)-indanamine (R-5) (70 mg, 0.53 mmol),K2CO3(76 mg, 0.53 mmol) and propargyl chloride (39.4 L,0.53 mmol) in acetonitrile (5.3 mL) was stirred at 60C for 16 h.After this time, the solvent was evaporated under reduced pres-sure and the crude product was diluted with 10 mL of a 10% NaOHsolution. The resulting aqueous solution was extracted with CH2Cl2(3 × 50 mL) and the organic phases were combined and driedwith Na2SO4, filtered and the solvent evaporated under reducedpressure. The reaction crude was finally purified by flash chro-matography on silica gel (40-60% EtOAc/hexane) affording thecorresponding (R)-N-propargyl-1-aminoindan (R-6) as an orangeliquid in 79% yield.

References:

De Mattos, Marcos Carlos;De Fonseca, Thiago Sousa;Da Silva, Marcos Reinaldo;De Oliveira, Maria Da Concei??o Ferreira;De Lemos, Telma Leda Gomes;De Marques, Ricardo Araújo [Applied Catalysis A: General,2015,vol. 492,# 1,p. 76 - 82]

FullText

Rasagiline Related Search: