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ChemicalBook CAS DataBase List RARECHEM AL BW 0442
56622-54-9

RARECHEM AL BW 0442 synthesis

8synthesis methods
-

Yield:56622-54-9 90%

Reaction Conditions:

with ammonia;hydrogen in methanol at 20; for 2 h;

Steps:

12 Preparation of (6-methylpyridin-3-yl) methanamine
Procedure H: To a mixture of 6-methylnicotinonitrile (300 mg, 2.54 mmol) in MeOH/NH3 (7N, 10mL), was added Raney Ni (50 mg). The reaction mixture was stirred at RT for 3 h under H2. It was then filtered, and the filtrate concentrated in vacuo to give 6- methylpyridin-3-yl) methanamine as a yellow oil (280 mg, 90%). LC-MS (ESI): m/z (M+1)+ = 123.30.

References:

REMEDY PLAN, INC.;CRIMMINS, Gregory, Thomas;DE JESúS DIAZ, Dennise, Alexandra;BHURRUTH-ALCOR, Yushma WO2019/213570, 2019, A1 Location in patent:Paragraph 0331; 0402-0404

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