Quinidine synthesis
- Product Name:Quinidine
- CAS Number:56-54-2
- Molecular formula:C20H24N2O2
- Molecular Weight:324.42
![1(2H)-Quinolinecarboxylic acid, 4-[(2R,3R)-3-[[(3R,4S)-3-ethenyl-1-[[2-(trimethylsilyl)ethoxy]carbonyl]-4-piperidinyl]methyl]-2-oxiranyl]-6-methoxy-, 2-(trimethylsilyl)ethyl ester](/CAS/20210305/GIF/1207974-84-2.gif)
1207974-84-2
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56-54-2
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Yield:56-54-2 78%
Reaction Conditions:
Stage #1: 2-(trimethylsilyl)ethyl 6-methoxy-4-((2R,3R)-3-(((3R,4S)-1-((2-(trimethylsilyl)ethoxy)carbonyl)-3-vinylpiperidin-4-yl)methyl)oxiran-2-yl)quinoline-1(2H)-carboxylatewith cesium fluoride in N,N-dimethyl-formamide at 180; for 0.25 h;Microwave irradiation;
Stage #2: with oxygen in N,N-dimethyl-formamide at 20; for 19 h;
References:
Illa, Ona;Arshad, Muhammad;Ros, Abel;McGarrigle, Eoghan M.;Aggarwal, Varinder K. [Journal of the American Chemical Society,2010,vol. 132,# 6,p. 1828 - 1830] Location in patent:supporting information; experimental part
130-95-0
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56-54-2
347 suppliers
$15.00/5g