Pyrroloquinoline quinone synthesis
- Product Name:Pyrroloquinoline quinone
- CAS Number:72909-34-3
- Molecular formula:C14H6N2O8
- Molecular Weight:330.21
With sodium carbonate In water at 30℃; for 24h;
Or with water; potassium carbonate In water at 25 - 80℃; Green chemistry; Industrial scale.
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72909-34-3
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Yield:72909-34-3 97%
Reaction Conditions:
Stage #1: 4,5-Dihydro-4,5-dioxo-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)esterwith lithium hydroxide;water in tetrahydrofuran at 0 - 17; for 31.5 h;
Stage #2: with hydrogenchloride;potassium chloride in tetrahydrofuran;water at 0; pH=5.3 - 6; for 1 h;
Stage #3: with sulfuric acid in water at 20; for 2.5 h;
Steps:
1.J; j; k
Into a 1-L, 3-neck flask equipped with a mechanical stirrer, a temperature probe, an addition funnel, a nitrogen purge system, and an ice bath were placed, 4,5-dioxo-4,5-dihydro- EPO
References:
WO2006/102642,2006,A1 Location in patent:Page/Page column 17-18; 1/6; 2/6; 3/6
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72909-34-3
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