Pyrrolo[2,3-d]pyrimidin-4-ol synthesis
- Product Name:Pyrrolo[2,3-d]pyrimidin-4-ol
- CAS Number:3680-71-5
- Molecular formula:C6H5N3O
- Molecular Weight:135.12
Pyrrolo[2,3-d]pyrimidin-4-ol is an important pharmaceutical intermediate. Pyrrolo[2,3-d]pyrimidin-4-ol can be synthesized by 7H-Pyrrolo[2,3-d]pyrimidine-4-ol and 6-Amino-5-(2,2-diethoxy-ethyl)-pyrimidin-4-ol.
7400-06-8
59 suppliers
$50.00/25mg
3680-71-5
405 suppliers
$6.00/1g
Yield:3680-71-5 60 mg (64%)
Reaction Conditions:
in hydrogenchloride;
Steps:
2 5.2.
6-Amino-5-(2,2-diethoxy-ethyl)-3H-pyrimidin-4-one (150 mg, 0.7 mmol) was dissolved in 5.0 mL of 1N HCl solution. The mixture was stirred at room temperature for 1 hour and the precipitate was filtered, washed with minimal amount of water and dried in a vacuum oven overnight to give 60 mg (64%) of 3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one as a white solid. 1H NMR (360 MHz, DMSO-d6)δ 11.83 (s, 1H, NH), 1.75 (s, 1H, NH), 7.80 (s, 1H), 7.01 (dd, J=2.65, 3.21 Hz, 1H), and 6.42 (dd, J=2.09, 3.21 Hz, 1H). MS m/e 134 [M+1 ]+.
References:
US2002/183319,2002,A1
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67831-84-9
37 suppliers
$80.00/100mg
3680-71-5
405 suppliers
$6.00/1g
67831-84-9
37 suppliers
$80.00/100mg
3680-71-5
405 suppliers
$6.00/1g
52133-67-2
193 suppliers
$8.00/1g
3680-71-5
405 suppliers
$6.00/1g
7400-05-7
37 suppliers
$60.00/250mg
3680-71-5
405 suppliers
$6.00/1g