ChemicalBook CAS DataBase List Propyl chloroacetate

Propyl chloroacetate synthesis

6synthesis methods

Product Name:Propyl chloroacetate
CAS Number:5396-24-7
Molecular formula:C5H9ClO2
Molecular Weight:136.58

71-23-8 Synthesis

71-23-8
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79-11-8
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5396-24-7
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Yield:5396-24-7 92%

Reaction Conditions:

with sulfuric acid for 6 h;Reflux;Fischer–Speier Esterification;

Steps:

General procedure for obtaining alkyl 2-chloroacetates via Fisher esterification (5a-5h)

General procedure: A mixture of 2-chloroacetic acid (20 mmol), the respective alcohol (4a-4h) (60 mL) and concentrated sulfuric acid (1 mL) was refluxed for 6 h. Afterwards,the excess solvent was rotary-evaporated, and the residue poured into cold water. The residue was transferred to a separation funnel containing 250 mL of water, and 100 mLof ethyl ether were then added. The organic phase was separated, washed repeatedly with 10% sodium bicarbonate until neutral pH and then dried with anhydrous NaSO4. Ethyl ether was rotary-evaporated, obtaining the respective esters (5a-5h).

References:

Barbosa-Filho, José M.;Brand?o, Maria Cláudia R.;Lima, Edeltrudes O.;Lira, Bruno F.;Neto, Hermes D.;Souza, Helivaldo D. S.;Trindade, Emmely O.;de Athayde-Filho, Petr?nio F. [Journal of the Brazilian Chemical Society,2020,vol. 31,# 8,p. 1668 - 1678]

71-23-8 Synthesis

71-23-8
760 suppliers
$12.00/100g

79-04-9 Synthesis