Primidone synthesis

6synthesis methods

Product Name:Primidone
CAS Number:125-33-7
Molecular formula:C12H14N2O2
Molecular Weight:218.25

Primidone, 5-ethyl-5-phenylhexahydropyrimidinedione-4,6 (9.2.1) is synthesized by reacting ethylphenylmalonic acid diamide with formamide [5,6]. An alternative method is the electrolytic reduction of phenobarbital or the catalytic reduction of the appropriate 2-thiobarbituric acid [7].

5-ethyldihydro-5-phenyl-2-thioxopyrimidine-4,6(1H,5H)-dione

2753-74-4
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125-33-7
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: 44 percent / 17 h / 22 °C / Irradiation
2: 42 percent / butan-1-ol / 17 h / 22 °C / Irradiation

References:

Paluchowska;Bojarski [Archiv der Pharmazie,1988,vol. 321,# 6,p. 343 - 344]

FullText

4,6(1H,5H)-Pyrimidinedione,5-ethyl-5-phenyl-(5CI)

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125-33-7
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References

7206-76-0
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125-33-7
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$5.00/25mg

References

50-06-6
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125-33-7
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References

64-18-6 Synthesis

64-18-6
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7206-76-0
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125-33-7
262 suppliers
$5.00/25mg

References

Primidone Related Search:

Diphenyl ether Triphenylphosphine Silver sulfadiazine PHENYL VALERATE Ethyl acetate Sulfadiazine Phenyl salicylate Ethyl maltol Ethanol DIHYDRO-5-PHENYL-5-PROPYL-4,6(1H,5H)-PYRIMIDINEDIONE