Pregabalin Impurity 7 synthesis
- Product Name:Pregabalin Impurity 7
- CAS Number:1094517-98-2
- Molecular formula:C16H32N2O7
- Molecular Weight:364.44
Yield:-
Reaction Conditions:
in water at 40 - 45; for 0.5 h;
Steps:
5
Example 5: Preparation of 3-(aminomethyl)N,N-diethyl-5-methyI hexanamide D(-) tartarate salt.; 3 -methyl amino N,N-diethyl-5 -methyl hexanamide (10 grams) was suspended in water and added D (-) tartaric acid (7 grams). The reaction mixture was slowly heated to 40-45°C and stirred for 30 min and filtered to remove the un-dissolved material. The filtrate was cooled to 20°C and stirred at 15-20° C for 1 hour. Filtered the solid obtained, washed with water and dried the material at 40-45°C to obtain the title compound.Yield: 6.1 grams.Specific optical Rotation: [α]D25 = -9.2° (c=l, water)
References:
WO2009/1372,2008,A2 Location in patent:Page/Page column 27