ChemicalBook CAS DataBase List Nonivamide

Nonivamide synthesis

12synthesis methods

Product Name:Nonivamide
CAS Number:2444-46-4
Molecular formula:C17H27NO3
Molecular Weight:293.4

From nonanyl chloride and vanillylamine.

1196-92-5
38 suppliers
$544.00/500g

112-05-0 Synthesis

112-05-0
520 suppliers
$8.00/25g

2444-46-4
512 suppliers
$5.00/100mg

Yield:2444-46-4 99%

Reaction Conditions:

with 2-((N,N-diisopropylamino)methyl)-4-cyanophenylboronic acid in fluorobenzene at 85; for 3.5 h;Molecular sieve;Green chemistry;Reagent/catalyst;Solvent;Temperature;

Steps:

2-9

Add 2-((N,N-diisopropyl)methyl-4-cyano)phenylboronic acid (0.0327mol, 10mol%) to 200ml fluorobenzene in a 500ml three-necked flask, add active molecular sieve and stir, add 3 at room temperature -Methoxy-4-hydroxybenzylamine 50g (0.327mol), stir and heat to 85°C to reflux, add 43g (0.272mol) n-nonanoic acid dropwise to the dropping funnel, keep refluxing and continue to stir for 3.5h, after the reaction, the temperature is cooled to room temperature , Add 100ml of water and stir for 5min, then stand for layering, take the oily layer, recover dichloromethane by vacuum distillation at 55°C to obtain a light yellow transparent liquid, stop vacuum distillation, cool the remaining liquid to room temperature, stir vigorously for 35min, white solid powder 82.3g, yield 99.0%, HPLC purity 99.5%.

References:

CN111875514,2020,A Location in patent:Paragraph 0005; 0032-0051