ChemicalBook CAS DataBase List N1,N1-DIMETHYL-4-NITROBENZENE-1-SULFONAMIDE

N1,N1-DIMETHYL-4-NITROBENZENE-1-SULFONAMIDE synthesis

7synthesis methods

Product Name:N1,N1-DIMETHYL-4-NITROBENZENE-1-SULFONAMIDE
CAS Number:17459-03-9
Molecular formula:C8H10N2O4S
Molecular Weight:230.24

124-40-3
518 suppliers
$18.00/100ml

98-74-8
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$10.00/5g

N1,N1-DIMETHYL-4-NITROBENZENE-1-SULFONAMIDE

17459-03-9
21 suppliers
$59.56/1g

Yield:17459-03-9 96%

Reaction Conditions:

in tetrahydrofuran at 0 - 20; for 2 h;

Steps:

50

4-NITROBENZENESULFONYL chloride (2.22 g, 10 mmol) was added to a solution of dimethylamine (10 mL, 2.0 M in THF, 20 mmol) at 0°C. The reaction was stirred at 0°C for 1 h and then at room temperature for additional 1 h. The THF was removed under vacuum, more water was added, and the precipitate was collected by filtration and dried to afford 450 (2.20 g, 96% yield). Data for 450 : 1HNMR (300 MHz, CDC13-CD30D) : 8 8.33 (d, J= 9 Hz, 2H), 7.90 (d, J= 9 Hz, 2H), 2.70 (s, 6H).

References:

WO2004/29066,2004,A2 Location in patent:Page/Page column 312

87-52-5 Synthesis