ChemicalBook CAS DataBase List N-methyl-N-phenylurethane

N-methyl-N-phenylurethane synthesis

8synthesis methods

Product Name:N-methyl-N-phenylurethane
CAS Number:2621-79-6
Molecular formula:C10H13NO2
Molecular Weight:179.22

541-41-3
6 suppliers
$19.39/5g

100-61-8 Synthesis

100-61-8
391 suppliers
$8.00/1g

2621-79-6
47 suppliers
$33.39/250mg

Yield: 88%

Reaction Conditions:

Stage #1:N-methylaniline with triethylamine in dichloromethane for 0.333333 h;
Stage #2:chloroformic acid ethyl ester at 20 - 25;

Steps:

Intermediate S2-A Ethyl methyl (phenyl) carbamate
[00186] A solution of N-methylaniline (30 g, 0.28 mol) in DOM (100 mL) was treatedwith triethylamine (45 mL, 0.33 mol) and stirred for 20 mi Ethyl chloroformate (32 mL, 0.33mol) was added over 25 mm with ice bath cooling maintaining the temperature at <25 °0. The reaction mixture was stirred at room temperature overnight, then poured into water (400 mL), acidified with 2 M HCl and extracted with EtOAc (700 mL). The organic layer was separated and washed with brine (400 mL), dried over Na2SO4 and evaporated to dryness to yield ethyl methyl(phenyl)carbamate (44 g, 0.25 mol, 88%).[00187] 1H NMR (300MHz, ODd3) O = 7.40-7.32 (m, 2H), 7.30-7.19 (m, 3H), 4.19(q, J= 7.1 Hz, 2H), 3.32 (5, 3H), 1.25 (t, J= 7.1 Hz, 3H)

References:

CANCER RESEARCH TECHNOLOGY LIMITED;MCGONAGLE, Alison E.;JORDAN, Allan M.;WASZKOWYCZ, Bohdan;HUTTON, Colin P.;WADDELL, Ian D.;HITCHIN, James R.;SMITH, Kate M.;HAMILTON, Niall M. WO2016/97749, 2016, A1 Location in patent:Paragraph 00186; 00187