ChemicalBook CAS DataBase List 4-Bromo-2-fluoro-N-methylbenzamide

4-Bromo-2-fluoro-N-methylbenzamide synthesis

5synthesis methods

Product Name:4-Bromo-2-fluoro-N-methylbenzamide
CAS Number:749927-69-3
Molecular formula:C8H7BrFNO
Molecular Weight:232.05

593-51-1 Synthesis

593-51-1
540 suppliers
$21.00/100g

112704-79-7 Synthesis

112704-79-7
517 suppliers
$15.00/5 g

749927-69-3
286 suppliers
$40.00/1 g

Yield:749927-69-3 100%

Reaction Conditions:

with (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 2 h;

Steps:

Compound 49: (4-Bromo-2-fluoro-benzyl)-methyl-amine.
Compound 49: (4-Bromo-2-fluoro-benzyl)-methyl-amine. (1029) A mixture of 4-bromo-2-fluorobenzoic acid (1.0 equiv.), methylamine hydrochloride (1.1 equiv.), benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (1.1 equiv.) and diisopropylethylamine (3.3 equiv.) in dichloromethane (0.20 mol.L^-1) was stirred for 2 hours at room temperature. The reaction mixture was hydrolyzed and extracted twice with dichloromethane. The organic layers were combined, washed with brine, dried over MgSO₄, concentrated, and purified by flash column chromatography on silica gel (10% to 50% EtOAc in cyclohexane) to afford the intermediate methylamide as a white solid in quantitative yield.

References:

MAVALON THERAPEUTICS LIMITED;SCHANN, Stephan;MAYER, Stanislas;MANTEAU, Baptiste WO2017/81483, 2017, A1 Location in patent:Page/Page column 228-229

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112704-79-7 Synthesis

112704-79-7
517 suppliers
$15.00/5 g

74-89-5 Synthesis