ChemicalBook CAS DataBase List N-Methyl-1-(4-nitrophenyl)methanesulfonamide

N-Methyl-1-(4-nitrophenyl)methanesulfonamide synthesis

5synthesis methods

Product Name:N-Methyl-1-(4-nitrophenyl)methanesulfonamide
CAS Number:85952-29-0
Molecular formula:C8H10N2O4S
Molecular Weight:230.24

4025-75-6 Synthesis

4025-75-6
103 suppliers
$6.00/250mg

N-Methyl-1-(4-nitrophenyl)methanesulfonamide

85952-29-0
97 suppliers
$24.00/100mg

Yield:-

Reaction Conditions:

with methylamine in dichloromethane

Steps:

1.a a
The organic layer was separated, dried over anhydrous sodium sulphate, filtered and evaporated to give 4-nitrobenzyl sulphonyl chloride (48.9 g, 83%) which was pure by ¹ H NMR. Methylamine gas was bubbled through a solution of 4-nitrobenzyl sulphonyl chloride (37.9 g, 0.16 mol), in dichloromethane (325 ml), until uptake had ceased (0.5 h). The resulting solid was filtered, washed with H₂ and dried under vacuum to give the title-sulphonamide (32.5 g, 88%), δ(250MHz, D₆ -DMSO) 2.61 (3H, s, Me), 4.55 (2H, s, CH₂), 7.06 (1H, s, NH), 7.66 (2H, d, J=8.7Hz, Ar-H), 8.25 (2H, d, J=8.7Hz, Ar-H).

References:

Merck Sharp & Dohme Ltd. US5854247, 1998, A

36639-50-6 Synthesis