Methyl propiolate synthesis
1synthesis methods
- Product Name:Methyl propiolate
- CAS Number:922-67-8
- Molecular formula:C4H4O2
- Molecular Weight:84.07
Yield:922-67-8 73%
Reaction Conditions:
Stage #1: propynoic acid methyl esterwith n-butyllithium in tetrahydrofuran;hexane at -78; for 1 h;
Stage #2: carbon dioxide in tetrahydrofuran;hexane at 20; for 1 h;
References:
Gherbovet;Sánchez-Murcia, Pedro A.;García Alvarez;Bignon;Thoret;Gago;Roussi [Organic and Biomolecular Chemistry,2015,vol. 13,# 10,p. 3144 - 3154]