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ChemicalBook CAS DataBase List Methyl benzoylformate

Methyl benzoylformate synthesis

14synthesis methods

Product Name:Methyl benzoylformate
CAS Number:15206-55-0
Molecular formula:C9H8O3
Molecular Weight:164.16

101-41-7 Synthesis

101-41-7
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$15.00/25mL

15206-55-0
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$5.00/10g

Yield:15206-55-0 92%

Reaction Conditions:

with tert.-butylhydroperoxide;phosphomolybdic acid;copper diacetate in water;acetonitrile at 90;

Steps:

7 Example 7
The synthetic steps of ethyl benzoate are:Phenylacetate0.150 g (1 mmol) was added to 1.5 mL of a mixed solvent of water and acetonitrile(Volume ratio 2: 1), to which tert-peroxide is added710 μL (5 mmol) of 70% aqueous solution,After stirring well, add 6 mg (3 mol%) of copper acetate and 18 mg (1 mol%) of phosphomolybdic acid,The reaction was performed at 90 ° C, and the reaction was monitored by TLC until the reaction of the raw materials was completed, and extracted with ethyl acetate.(3 times * 10mL), the combined organic phases were washed once with saturated brine,Dry over anhydrous sodium sulfate and remove the solvent by evaporation in vacuo.Purification by column chromatography to obtain the target productEthyl benzoateYield: 92%.

References:

Inner Mongolia University for Nationalities;Li Peihe;Liu Jinghai;Wang Yingying;Duan Limei CN110317131, 2019, A Location in patent:Paragraph 0076-0078