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ChemicalBook CAS DataBase List Methyl 6-aminonicotinate
36052-24-1

Methyl 6-aminonicotinate synthesis

7synthesis methods
-

Yield:36052-24-1 89%

Reaction Conditions:

with thionyl chloride at 80; for 12 h;Inert atmosphere;

Steps:

Step a
General procedure: A mixture of 4-aminobenzoic acid (32-34, 5.0 mmol), thionyl chloride(1.487 g, 5.0 mmol), and MeOH (20.0 mL) was flushed with argon, and stirred at80°C for 12 hours. Remove reaction solvent by rota vapor. The reaction mixture wasneutralized with NaHCO3(sat) (20.0 mL) and extracted with ethyl acetate (100 mL ×3). The combined organic extracts were washed with brine, dried by Na2SO4, filtered,and evaporated, to get cmopound 35-37 (63-89%) as a white solid.

References:

Hsieh, Hao-Yu;Chuang, Hsiao-Ching;Shen, Fang-Hsiu;Detroja, Kinjal;Hsin, Ling-Wei;Chen, Ching-Shih [European Journal of Medicinal Chemistry,2017,vol. 140,p. 42 - 51] Location in patent:supporting information

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