Methyl 6-aminonicotinate synthesis
- Product Name:Methyl 6-aminonicotinate
- CAS Number:36052-24-1
- Molecular formula:C7H8N2O2
- Molecular Weight:152.15
67-56-1
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3167-49-5
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36052-24-1
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Yield:36052-24-1 89%
Reaction Conditions:
with thionyl chloride at 80; for 12 h;Inert atmosphere;
Steps:
Step a
General procedure: A mixture of 4-aminobenzoic acid (32-34, 5.0 mmol), thionyl chloride(1.487 g, 5.0 mmol), and MeOH (20.0 mL) was flushed with argon, and stirred at80°C for 12 hours. Remove reaction solvent by rota vapor. The reaction mixture wasneutralized with NaHCO3(sat) (20.0 mL) and extracted with ethyl acetate (100 mL ×3). The combined organic extracts were washed with brine, dried by Na2SO4, filtered,and evaporated, to get cmopound 35-37 (63-89%) as a white solid.
References:
Hsieh, Hao-Yu;Chuang, Hsiao-Ching;Shen, Fang-Hsiu;Detroja, Kinjal;Hsin, Ling-Wei;Chen, Ching-Shih [European Journal of Medicinal Chemistry,2017,vol. 140,p. 42 - 51] Location in patent:supporting information
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18107-18-1
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36052-24-1
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$10.00/1g
3167-49-5
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36052-24-1
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3167-49-5
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7664-93-9
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36052-24-1
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21550-48-1
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36052-24-1
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