ChemicalBook CAS DataBase List Methyl 3-AMino-5-broMo-2-Methylbenzoate

Methyl 3-AMino-5-broMo-2-Methylbenzoate synthesis

6synthesis methods

Product Name:Methyl 3-AMino-5-broMo-2-Methylbenzoate
CAS Number:1000342-11-9
Molecular formula:C9H10BrNO2
Molecular Weight:244.09

220514-28-3 Synthesis

5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE

220514-28-3
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$10.00/1g

1000342-11-9
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$6.00/1g

Yield:1000342-11-9 99.1%

Reaction Conditions:

with iron;ammonium chloride in ethanol;water at 90; for 1 h;

Steps:

[01040] Step 4: methyl 3-amino-5-bromo-2-methylbenzoate[01041] A mixture of methyl 5-bromo-2-methyl-3-nitrobenzoate (17 g, 62.0 mmol) in ethanol (85 mL) had NH₄C1 solution (17 g in 85 mL water, 317.8 mmol) followed by Fe powder (27.8 g, 498.1 mmol) added. The resulting reaction mixture was stirred at 90 °C for lh. On completion, the reaction mixture was filtered and the filtrate was concentrated till dry. The resulting solid was dissolved in sat. sodium bicarbonate solution and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate and concentrated to afford solid methyl 3-amino-5-bromo-2-methylbenzoate (15 g, 99.1%).

References:

WO2012/118812,2012,A2 Location in patent:Page/Page column 312