ChemicalBook CAS DataBase List METHYL 2-AMINO-5-CHLORO-3-NITROBENZOATE

METHYL 2-AMINO-5-CHLORO-3-NITROBENZOATE synthesis

6synthesis methods

Product Name:METHYL 2-AMINO-5-CHLORO-3-NITROBENZOATE
CAS Number:84228-49-9
Molecular formula:C8H7ClN2O4
Molecular Weight:230.61

67-56-1 Synthesis

67-56-1
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6324-51-2 Synthesis

6324-51-2
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84228-49-9
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Yield:84228-49-9 61%

Reaction Conditions:

with thionyl chloride at 0 - 80; for 12 h;

Steps:

21.4 Step 4. Methyl 2-amino-5-chloro-3-nitrobenzoate.

Step 4. Methyl 2-amino-5-chloro-3-nitrobenzoate. To a solution of 2-amino-5-chloro-3-nitrobenzoic acid (0.645 g, 3 mmol) in MeOH (10 mL) 0°C was added SOCl₂ (0.7 g, 6 mmol). The mixture reaction was stirred at 80°C for 12 nr, then cooled to r.t. and concentrated under reduced pressure. The residue was purified by column chromatography to give methyl 2-amino-5-chloro-3-nitrobenzoate (420 mg, 61% yield). LC-MS: m/z 231(M+H)⁺.

References:

WO2014/176258,2014,A1 Location in patent:Page/Page column 67

635-21-2 Synthesis