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ChemicalBook CAS DataBase List METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE
394223-19-9

METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE synthesis

3synthesis methods
-

Yield: 90%

Reaction Conditions:

with potassium carbonate at 55; for 1 h;

Steps:


Add to ethyl 4-azaindole-2-carboxylate 4a (42.3 mmol) in MeOH (50 mL), K2CO3 (1.20 equiv, 50.7 mmol) and stir the suspension with heating to 55° C. for 1 h. Monitor the reaction by tlc (Et2O/hept). When complete, concentrate the reaction in vacuo, dilute with H2O and stir for 15 min. Collect the solid by filtration and dry in a vacuum oven at 65° C. for 3 h to afford about 90% to about 100% of the desired methyl 4-azaindole-2-carboxylate 5a.

References:

Aventis Pharmaceuticals Inc. US2005/131012, 2005, A1 Location in patent:Page/Page column 15

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