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ChemicalBook CAS DataBase List METHOXYPHENONE
41295-28-7

METHOXYPHENONE synthesis

2synthesis methods
-

Yield:41295-28-7 60%

Reaction Conditions:

in PPA

Steps:

2 Preparation of 4-methoxy-3,3'-dimethylbenzophenone
EXAMPLE 2 Preparation of 4-methoxy-3,3'-dimethylbenzophenone m-Toluic acid (13.6 g, 0.10 mole) and o-methylanisole (12.2 g, 0.10 mole) are combined in 50 ml of polyphosphoric acid (PPA) and warmed with stirring to 80°C for 2 hours. The cooled reaction mixture is then poured into ice water and extracted into ethyl acetate (200 ml) and washed with 5% sodium hydroxide to give 14.4 g of product (60%), m.p. 62°-4°C, upon removal of the solvent in vacuo.

References:

Rohm and Haas Company US3954875, 1976, A

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