ChemicalBook CAS DataBase List Losartan Carboxaldehyde

Losartan Carboxaldehyde synthesis

13synthesis methods

Product Name:Losartan Carboxaldehyde
CAS Number:114798-36-6
Molecular formula:C22H21ClN6O
Molecular Weight:420.89

114798-26-4
262 suppliers
$6.00/250mg

114798-36-6
83 suppliers
$50.00/1mg

Yield:114798-36-6 94%

Reaction Conditions:

with dipyridinium dichromate in N,N-dimethyl-formamide at 20 - 50; for 6 h;Alkaline conditions;

Steps:

2.2 (2) 5-aldehyde losartan

317g of losartan (0.75mol) was dissolved in DMF (1000mL) and was added in portions with stirring 418.5g of PDC. Temperature was not to exceed 50°C. After addition of PDC was complete, it was stirred at room temperature for 6 hours. The reaction solution was poured into 5000g of water. The solution was extracted three times with ethyl acetate (2500mL × 3). The combined organic phases was washed saturated brine (2500mL) then dried over anhydrous magnesium sulfate. it was filtered and concentrated to give 296g of a solid 5-aldehyde losartan, yield 94%

References:

CN105218527,2016,A Location in patent:Paragraph 0015

124750-67-0 Synthesis