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ChemicalBook CAS DataBase List L-Tyrosine Ethyl Ester Hydrochloride
4089-07-0

L-Tyrosine Ethyl Ester Hydrochloride synthesis

3synthesis methods
synthesis of L-Tyrosine Ethyl Ester Hydrochloride: Esterification of 25 g. ol L-tyrosine (0.014 mole) with ethanolic hydrogen chloride gave 24.1 g. of L-tyrosine ethyl ester hydrochloride (80%). Liberation of the ester by slurrying the hydrochloride in chloroform rollowed by the addition of chloroform saturated with ammonia, removal of the ammonium chloride by filtration and evaporation of the chloroform gave 19.4 g. of L-tyrosine ethyl ester (67%), m.p. 106-108 ° .
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Yield:4089-07-0 94.7%

Reaction Conditions:

with dichloro sulfoxideReflux;

Steps:

2

Weigh 18g of L-Tyr (tyrosine) and 100ml of ethanol into the reaction flask, add 120ml of SOCl2 (thionyl chloride) dropwise with stirring, and react under reflux. When TLC (Thin Layer Chromatography) detects that there is no L-Tyr (tyrosine) in the reaction system, the reaction is completed, and the reaction solution after the above reaction is vacuum concentrated to a volume of 20 ml, and 100 ml of petroleum ether is added to precipitate a white solid. After centrifugation and drying, 19.8 g of white solid was obtained with a yield of 94.7%.

References:

CN112094204,2020,A Location in patent:Paragraph 0057-0058

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