Ketamine hydrochloride synthesis
- Product Name:Ketamine hydrochloride
- CAS Number:1867-66-9
- Molecular formula:C13H16ClNO.ClH
- Molecular Weight:274.19
![KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL)(METHYLIMINO)METHYL]CYLCOPENTA-NOL)](/CAS/GIF/6740-87-0.gif)
6740-87-0
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1867-66-9
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Yield:1867-66-9 70%
Reaction Conditions:
with hydrogenchloride in ethanol at 175; under 12929 Torr; for 0.0833333 h;Flow reactor;Solvent;Temperature;Pressure;
Steps:
23 Example 23: Preparation of (/?,S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride, [R,S)- ketamine hydrochloride, roc-l-HCI) in flow
A solution of l-[(2-chlorophenyl)(methylimino)methyl]cyclopentanol (IVa) in absolute ethanol (0.36 M) was pumped at a flow rate of 0.24 mL min 1 with a HPLC pump, and a solution of a fourth additive in the form of a pharmaceutically acceptable acid which is HCI in absolute ethanol (0.9 M) was pumped at a flow rate of 0.16 mL min 1 with a metal-free HPLC pump. Both streams were mixed through a static PEEK T-mixer, and next reacted in a microfluidic reactor loop constructed from a PFA capillary embed in a copper coil (2 mL internal volume, corresponding to a residence time of 5 min). The reactor was operated at 175 °C under 250 psi of counter- pressure. The reactor effluent was collected and processed, affording (/?,S)-ketamine hydrochloride (roc-l-HCI) in 70% yield (> 99% purity, HPLC). This example shows the superior effect of this reaction step in flow versus this reaction step in batch (cfr examples 21 and 22) with an increase in the purity of the product obtained.
References:
UNIVERSITé DE LIèGE;TOUPY, Thomas;GERARDY, Romaric WO2019/129815, 2019, A1 Location in patent:Page/Page column 27; 28
6740-85-8
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1867-66-9
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873-32-5
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$9.00/1g
1867-66-9
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$15.00/1mg