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ChemicalBook CAS DataBase List KETAMINE HYDROCHLORIDE SELECTIVE NMDA AN TAGO
6740-88-1

KETAMINE HYDROCHLORIDE SELECTIVE NMDA AN TAGO synthesis

7synthesis methods
It is prepared by bromination of o-chlorophenyl cyclopentyl ketone, which is then reacted with methylamine to give the methylimino alcohol. Thermolysis of the imino hydrochloride yields ketamine by ring expansion :
Synthesis_6740-88-1
1867-66-9 Synthesis
Ketamine hydrochloride

1867-66-9
3 suppliers
$15.00/1mg

-

Yield:6740-88-1 99%

Reaction Conditions:

with sodium hydroxide in chloroform;water

Steps:

Preparation of (±)-ketamine free base
Racemic ketamine.HCI (15.0 g, 54.7 mmol) was dissolved in 100 mL of water under stirring. To the solution was added 100 mL CHCI3 and under vigorous stirring basified by drop-wise addition of a solution of 2.40 g NaOH (60 mmol) in 30 ml_ of water. The white precipitate that was formed was directly extracted into the CHCI3 layer (clear solution). The mixture was transferred into a separation funnel and separated. The aqueous phase was extracted again with 100 ml_ chloroform and then with 50 ml_ of chloroform. The combined chloroform layers were washed with 50 ml_ of water, dried over Na2SO4 and concentrated on a Rotavap to yield a white crystalline solid (solidified oil). Yield: 12.88 g of white solid (54.2 mmol, 99%); NMR confirmed ketamine free base. The procedure was repeated with 10.15 g (36.9 mmol) of racemic ketamine and yielded 8.73 g (36.7mmol, 99.5%) of free ketamine as a white solid.

References:

CHEN, Cheng Yi;FLOEGEL, Oliver;JUSTUS, Michael;MAURER, Adrian;REUTER, Karl;STRITTMATTER, Tobias;WEDEL, Tobias WO2016/180984, 2016, A1 Location in patent:Page/Page column 42-43

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