Idarubicin synthesis
- Product Name:Idarubicin
- CAS Number:58957-92-9
- Molecular formula:C26H27NO9
- Molecular Weight:497.49
23541-50-6
476 suppliers
$15.00/10mg
58957-92-9
119 suppliers
inquiry
Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: potassium carbonate; triflic azide / dichloromethane; water; methanol
2.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C
2.2: pH 2.5 / Cooling with ice
3.1: N-ethyl-N,N-diisopropylamine; pyridine / dmap / 1 h / 0 - 20 °C
4.1: triethylammonium formate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
5.1: triphenylphosphine / tetrahydrofuran
References:
Synbias Pharma Ltd. EP2518077, 2012, A1
![5,12-Naphthacenedione, 9-acetyl-7,8,9,10-tetrahydro-6,9,11-trihydroxy-7-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-, (7S,9S)-](/CAS/20211123/GIF/60660-74-4.gif)
60660-74-4
1 suppliers
inquiry
58957-92-9
119 suppliers
inquiry
60660-75-5
58 suppliers
$160.00/2.5mg
58957-92-9
119 suppliers
inquiry