ChemicalBook CAS DataBase List Ibandronate sodium monohydrate

Ibandronate sodium monohydrate synthesis

4synthesis methods

Product Name:Ibandronate sodium monohydrate
CAS Number:138926-19-9
Molecular formula:C9H24NNaO8P2
Molecular Weight:359.23

114084-78-5
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138926-19-9
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Yield:-

Reaction Conditions:

with sodium hydroxide in water; pH=4.3 - 4.4;Product distribution / selectivity;

Steps:

4; 5

Example 4 Ibandronic acid (10 g) is suspended in water (200 ml) and added with 1M NaOH to pH 4.3-4. 4. The resulting clear solution is filtered through a 0.22 micron filter, frozen to-40°C and lyophilized (< 100 mbar, 0-40°C), to give amorphous monosodium ibandronate with a water content of less than 2%. Example 5 Ibandronic acid (10 g) is suspended in water (200 ml) and added with 1M NaOH to pH 4.3-4. 4. The resulting clear solution is filtered through a 0. 22 micron filter and conveyed under pressure to a spray-drier (nozzle temperature = 180-200°C). Amorphous monosodium ibandronate identical to that of Example 1 is obtained.

References:

WO2005/63779,2005,A2 Location in patent:Page/Page column 6

1310-73-2 Synthesis