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ChemicalBook CAS DataBase List Fenbendazole
43210-67-9

Fenbendazole synthesis

5synthesis methods
Fenbendazole is a benzimidazole anthelmintic, which has high anthelmintic activity against gastrointestinal nematodes adults and larvae, but also has good effects on reticulate nematodes, fascioli and tapeworms. The synthetic method is that 5-Chloro-2-nitroaniline reacts with benzenethiol to obtain 5-phenylthio-2-nitroaniline, which is reduced by ferrous sulfate-iron powder to obtain 3-phenylthio-o-phenylenediamine and finally reacts with S-methyl-cyanamide methyl ester via cyclization to give benthiobenzimidazole.
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: K2CO3 / dimethylformamide / 6 h / Heating
2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr
3.1: NaOH / H2O / 0.67 h / 3 - 6 °C
3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C

References:

Cortes, Eduardo Cortes;Mendoza, Rafael Sosa;Gutierrez, Maximiliano Santibanez;De Cortes, Olivia Garcia-Mellado [Journal of Heterocyclic Chemistry,2004,vol. 41,# 2,p. 273 - 276]

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