Ethyl (R)-2-hydroxy-4-phenylbutyrate synthesis
- Product Name:Ethyl (R)-2-hydroxy-4-phenylbutyrate
- CAS Number:90315-82-5
- Molecular formula:C12H16O3
- Molecular Weight:208.26
64-17-5
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29678-81-7
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90315-82-5
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Yield:90315-82-5 98%
Reaction Conditions:
with sulfuric acid at 70; for 2 h;
Steps:
1.4
2.89 g of (R) -2-hydroxy-4-phenylbutanoic acid purified in the above Step 3)Was added to a 100 mL single-necked flask, 70 ml of absolute ethanol was added,And slowly stirring in the concentrated sulfuric acid 1.4g, drop the system slowly heated to 70 ° C.Hold 70 ° C to continue stirring, TLC monitoring reaction. 2 hours or so reaction is completed, stop heating,Down to 0 ° C, slowly add sodium bicarbonate solid 2.4 g neutralized concentrated sulfuric acid,Add to continue stirring after 10-15 minutes, filter, remove insoluble. The filtrate was concentrated,Remove excess ethanol. Evaporated to dryness to the system by adding 30 mL of water and extracted with 20 mL of ethyl acetate,Dispense, take the organic phase. The aqueous phase was extracted with ethyl acetate (10 mL * 2). Combine organic phase,The organic phase was washed once with 10 mL of saturated sodium bicarbonate solution, once with 10 mL of saturated brine,Dried over anhydrous sodium sulfate, spin dry, in colorless transparent liquid 3.28g, yield 98%. Purity> 99%, yesSelectivity> 99%.
References:
Suzhou Yinhang Biotechnology Co. Ltd.;Xie, XinKai;Huang, xiaofei;Zhang, JinXin;Zhang, RuiJie CN105777546, 2016, A Location in patent:Paragraph 0047; 0052
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90315-82-5
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90315-82-5
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64920-29-2
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90315-82-5
288 suppliers
$14.00/1g
64920-29-2
250 suppliers
$10.00/1g
90315-82-5
288 suppliers
$14.00/1g