Ethyl p-toluenesulfonate synthesis
- Product Name:Ethyl p-toluenesulfonate
- CAS Number:80-40-0
- Molecular formula:C9H12O3S
- Molecular Weight:200.25
Yield:80-40-0 90%
Reaction Conditions:
with pyridine at 0; for 3 h;Reagent/catalyst;
Steps:
1
200 ml of a three-necked flask was placed in an ice-water bath at 0 ° C, 3.82 g (20 mmol) of p-toluenesulfonyl chloride and 50 mL of pyridine (dry) were added, and the mixture was stirred with 1.02 mL (20 mmol) of ethanol and reacted for 3 hours. After completion of the reaction, 100 mL of distilled water was added and extracted with dichloromethane (3 * 20 mL). The organic layer was washed twice with 6M HCl (2 * 30 mL) and washed successively with saturated NaHCO3 (30 mL) and 20% NaCl (30 mL) Once, separated. The organic layer was dried over anhydrous Na2SO4 for 8 h, filtered to remove anhydrous Na2SO4, and the organic liquid was evaporated to a final colorless oil Ethyl 4-methylbenzenesulfonate (yield 90%).
References:
CN106631911,2017,A Location in patent:Paragraph 0010
103-19-5
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$19.00/5g
80-40-0
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$5.00/5g
