DIMETHYL-(2-PIPERIDIN-4-YL-ETHYL)-AMINE synthesis
- Product Name:DIMETHYL-(2-PIPERIDIN-4-YL-ETHYL)-AMINE
- CAS Number:102308-48-5
- Molecular formula:C9H20N2
- Molecular Weight:156.27
622-26-4
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98-88-4
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102308-48-5
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$65.00/50mg
![Methanone, [4-(2-hydroxyethyl)-1-piperidinyl]phenyl-](/CAS/20210111/GIF/152902-80-2.gif)
152902-80-2
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Yield:-
Reaction Conditions:
with sodium hydroxide;triethylamine in 1,4-dioxane;dichloromethane;water
Steps:
a 2-Chloroethyl 4-chlorophenyl ether
a) 4-(2-Dimethylaminoethyl)piperidine Benzoyl chloride (25.8 ml) in dichloromethane (20 ml) was added dropwise over 30 minutes to a mixture of 4-(2-hydroxyethyl)piperidine (26 g) in dichloromethane (250 ml) and triethylamine (16.3 ml) at 0° C. The mixture was allowed to warm to ambient temperature and stirred at this temperature for 1 hour. The mixture was washed with sodium bicarbonate solution and then dried and evaporated to give a colourless oil. The oil was dissolved in 1,4-dioxane (250 ml) and then a solution of sodium hydroxide (5.0 g) in water (20 ml) was added and the mixture stirred at ambient temperature for 16 hours and then at 60° C. for 6 hours. The mixture was evaporated to near dryness, basified with 2M sodium hydroxide solution and the product extracted into dichloromethane to give 1-benzoyl-4-(2-hydroxyethyl)piperidine as an oil.
References:
KNOLL Aktiengesellschaft US5760035, 1998, A
38223-06-2
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102308-48-5
25 suppliers
$65.00/50mg