ChemicalBook CAS DataBase List Cylopropylmethyl chloride

Cylopropylmethyl chloride synthesis

8synthesis methods

Product Name:Cylopropylmethyl chloride
CAS Number:5911-08-0
Molecular formula:C4H7Cl
Molecular Weight:90.55

2516-33-8
293 suppliers
$9.00/1g

5911-08-0
209 suppliers
$25.00/1 g

Yield:5911-08-0 94%

Reaction Conditions:

with 1,3,5-trichloro-2,4,6-triazine in acetonitrile at -10 - 25; for 5 h;Solvent;Temperature;

Steps:

3
Add four 3kg acetonitrile into a four neck flask , then stirring, and cooled to -10 ° C; then1216g TCT added in batches within 30min at a controlled Temperature of 0 ° C, stirred for 5min and 721g of CPMO was added dropwise within 2 hours at the controlled temperature of below 0 ° C; The addition was complete, stirring the reaction for 3 hours at 0 ° C, then stop cooling, naturally raising the temperature to 25 ° C. take t sample control, and when CPMO completely reacted, then the reaction was completed. [0057] B) the formulated 4kg of 30% sodium hydroxide solution was cooled to about 5 ° C. at a Control dropping temperature which does not exceed 10 ° C, the reaction liquid drops into the caustic soda (Sodium hydroxide) and dropwise addition was completed in 2 hours. Stirred for 30 min. [0058] C) The product was extracted twice in 2 kg of dichloromethane and the dichloromethane was combined. The dichloromethane layer was washed three times with 300 ml of water. [0059] D) distillation of dichloromethane layer at atmospheric pressure to obtain products: 851g, purity 99.6%: Yield: 94%.

References:

Hangzhou Shengfutai New Materials Technology Co., Ltd.;Fu Chengfang CN107324969, 2017, A Location in patent:Paragraph 0038; 0047; 0055-0059

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