Cyclobutyl bromide synthesis
- Product Name:Cyclobutyl bromide
- CAS Number:4399-47-7
- Molecular formula:C4H7Br
- Molecular Weight:135
3721-95-7
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4399-47-7
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Yield:4399-47-7 75 %
Reaction Conditions:
Stage #1: Cyclobutanecarboxylic acidwith potassium tert-butylate in ethanol at 50;Inert atmosphere;
Stage #2: with 2,2'-azobis(isobutyronitrile);bromine in chlorobenzene at 70;Inert atmosphere;
Steps:
2; 6
Reference Example 2 Under a nitrogen atmosphere, 2.24 g of tert-butoxy potassium was added to a mixture of 2 g of cyclobutanecarboxylic acid and 20 g of ethanol at 20°C, and the mixture was stirred at 50°C for 1 hour.The resulting mixture was concentrated to obtain 2.54 g of potassium cyclobutanecarboxylate with a water concentration of 0.20 wt %.Example 6 In a nitrogen atmosphere, a mixture of 0.5 g of potassium cyclobutanecarboxylate obtained in Reference Example 2, 0.03 g of AIBN, and 3.0 g of monochlorobenzene was added with 0.58 g of bromine and 2.0 g of monochlorobenzene at 70°C. The mixture was added dropwise over 2 hours.The resulting mixture was analyzed by gas chromatography internal standard method and confirmed to contain 0.36 g of cyclobutyl bromide.(Yield 75.0%)
References:
WO2022/249788,2022,A1 Location in patent:Paragraph 0029-0030
2516-33-8
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4399-47-7
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$14.14/1gm:
7051-34-5
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42392-28-9
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4399-47-7
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2516-33-8
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5162-44-7
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4399-47-7
231 suppliers
$14.14/1gm:
7051-34-5
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5911-08-0
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5162-44-7
366 suppliers
$10.00/5G
4399-47-7
231 suppliers
$14.14/1gm:
7051-34-5
422 suppliers
$6.00/1g