ChemicalBook CAS DataBase List Coumarin 334

Coumarin 334 synthesis

5synthesis methods

Product Name:Coumarin 334
CAS Number:55804-67-6
Molecular formula:C17H17NO3
Molecular Weight:283.32

63149-33-7
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141-97-9 Synthesis

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55804-67-6
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$59.70/500mg

Yield: 79%

Reaction Conditions:

with piperidine in ethanol for 6 h;Reflux;

Steps:

1 Synthesis of coumarin derivatives represented by formula (III)
The 8-hydroxy-nonalonidine-9-carbaldehyde (0.6518g, 3mmol), ethyl acetate (0.7748g, 3mmol) and piperidine (0.5ml, 3mmol) represented by formula (II) were dissolved in 24mL of anhydrous In ethanol.The mixture was heated and refluxed for 6 hours, then cooled to room temperature.The suspension was then collected by filtration and washed with cold absolute ethanol.Finally, the product was dried under vacuum to obtain orange crystals, and the coumarin derivative represented by formula (III) (0.6715 g, 79%) was obtained.

References:

Zhou Xuejun;Xu Zhencai;Wang Xiaofeng;Zou Yuxia;Duan Tingting;He Rong;Wang Fangwu;Qin Jidong CN112010865, 2020, A Location in patent:Paragraph 0009; 0035-0038