cis-1,4-Dichloro-2-butene synthesis
- Product Name:cis-1,4-Dichloro-2-butene
- CAS Number:1476-11-5
- Molecular formula:C4H6Cl2
- Molecular Weight:125
6117-80-2
198 suppliers
$10.00/5g
1476-11-5
236 suppliers
$14.00/5g
Yield:1476-11-5 84%
Reaction Conditions:
with thionyl chloride at 20; for 16 h;Cooling with ice;
Steps:
2.1 Step 1 - Synthesis of (Z)-1,4-dichlorobut-2-ene
To an ice-cooled solution of (Z)-but-2-ene-1,4-diol (150 g, 1.7 mol) was added thionyl chloride (250 mL) over 40 mm. The resulting mixture was warmed to 20 °C. After 16the reaction mixture was diluted with water (500 mL), and the resulting mixture was extracted with ethyl acetate (2 L). The collected organic was dried over anhydrous sodium sulfate, filtered, and concentrated to give product as a brown oil (180 g, 84% yield).
References:
F. HOFFMANN-LA ROCHE AG;GENENTECH, INC.;LYSSIKATOS, Joseph P.;LIU, Wen;SIU, Michael;ESTRADA, Anthony;PATEL, Snahel;LIANG, Guibai;HUESTIS, Malcolm;CHEN, Kevin WO2015/91889, 2015, A1 Location in patent:Page/Page column 119
1708-29-8
254 suppliers
$19.25/25g
1476-11-5
236 suppliers
$14.00/5g
110-57-6
169 suppliers
$55.10/5g
1476-11-5
236 suppliers
$14.00/5g
7647-01-0
0 suppliers
$10.00/10g
6117-80-2
198 suppliers
$10.00/5g
1476-11-5
236 suppliers
$14.00/5g
821-10-3
203 suppliers
$11.00/1g
110-83-8
316 suppliers
$11.00/25g
1476-11-5
236 suppliers
$14.00/5g