Cinchocaine synthesis

5synthesis methods

Product Name:Cinchocaine
CAS Number:85-79-0
Molecular formula:C20H29N3O2
Molecular Weight:343.46

87864-14-0 Synthesis

2-Chloro-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide

87864-14-0
82 suppliers
$19.00/100mg

71-36-3 Synthesis

71-36-3
1043 suppliers
$14.00/25mL

85-79-0
179 suppliers
$39.00/1mg

Yield:85-79-0 96.4%

Reaction Conditions:

with sodium hydroxide in hexane;Reflux;Solvent;

Steps:

1

150 g of 2-chloro-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide, 39 g of sodium hydroxide were added to 90 g of n-butanol,In a solution of 600 g of n-hexane, slowly raise the temperature to reflux and separate the water.After the water is divided, the temperature is lowered to room temperature, and deionized water is added for stirring for 1 hour, and the layering is static for 0.5 hour.The aqueous phase was separated by liquid separation, and the organic phase was further stirred by adding deionized water for 0.5 h. The aqueous phase was separated by liquid separation, and the organic phase was stirred and crystallized at 0 to 10 ° C for 8 hours.Filtration and drying gave 162.5 g of cinchine product, the molar yield was 96.4%, and the liquid phase purity was 99.9%.

References:

CN108003097,2018,A Location in patent:Paragraph 0020-0022; 0023-0025; 0026-0028