ChemicalBook CAS DataBase List 2-HYDROXY-4-METHYLQUINOLINE

2-HYDROXY-4-METHYLQUINOLINE synthesis

10synthesis methods

Product Name:2-HYDROXY-4-METHYLQUINOLINE
CAS Number:607-66-9
Molecular formula:C10H9NO
Molecular Weight:159.18

491-35-0
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607-66-9
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$8.00/5g

Yield:607-66-9 94%

Reaction Conditions:

with water;chloroacetic acid ethyl ester in ethyl acetate for 0.416667 h;Microwave irradiation;

Steps:

3 Example 3: Preparation of 4-methyl-2-(1H)-quinolinone
In a 50mL pressure-resistant reaction tube, 4-3.4% quinoline was added in sequence, Ethyl chloroacetate 1.23g, Distilled water 0.54g, 20 ml of ethyl acetate, The resulting mixture was subjected to microwave irradiation for 25 minutes in a 300 W microwave stirring reaction apparatus. Washing the reaction solution with hot water, Liquid separation, Collect organic phase, Ethyl acetate and ethyl chloroacetate were removed under reduced pressure. Recrystallization to give the corresponding 4-methyl-2-(1H)-quinolinone 1.50g, The yield was 94%.

References:

Hunan University of Science and Engineering;Changsha University of Science and Technology;He Weimin;Cao Zhong;Lu Linghui;Peng Sha;He Weibao;Zeng Fei;Bao Wenhu;Wang Yi CN108503582, 2018, A Location in patent:Paragraph 0065; 0066

FullText

32315-10-9 Synthesis