Chloromethyl acetate synthesis
- Product Name:Chloromethyl acetate
- CAS Number:625-56-9
- Molecular formula:C3H5ClO2
- Molecular Weight:108.52
75-36-5
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625-56-9
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Yield:625-56-9 94%
Reaction Conditions:
with formaldehyd;zinc(II) chloride at 0 - 90; for 19 h;Inert atmosphere;
Steps:
49.1 Synthesis of chloromethyl acetate
Acetyl chloride (5g,0.O6mol)was addeddropwisetoamixtureofparaform-aldhyde (8.5 g, 0.06 mol) and anhydrous zinc chloride(0.175 g, 0.02 mol) at 0° C. under Argon. The reaction mixture was warmed to room temperature and stirred for 1hour, then heated to 90° C. for 18 hours. The solid was filtered off washed with dichloromethane, and the filtrate was concentrated under vacuum at 37° C. to provide thedesired product (6.6 g, 94% yield). The product was useddirectly (without purification) in to next step and stored with activated molecular sieves (4° A).
References:
Alkermes Pharma Ireland Limited;Blumberg, Laura Cook;Remenar, Julius F.;Almarsson, Orn;Zeidan, Tarek A. US9102618, 2015, B2 Location in patent:Page/Page column 426
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