ChemicalBook CAS DataBase List Carbazole

Carbazole synthesis

11synthesis methods

Product Name:Carbazole
CAS Number:86-74-8
Molecular formula:C12H9N
Molecular Weight:167.21

9H-Carbazole, 9-[(4-methylphenyl)sulfonyl]-

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Yield:86-74-8 98%

Reaction Conditions:

with sodium hydride in N,N-dimethyl acetamide at 60; for 3 h;Inert atmosphere;

Steps:

General procedure for the detoyslation reaction.

General procedure: To a suspension solution of NaH (0.4 mmol, 2.0 equiv) in dry DMA (1.0 mL) under N₂ was added dropwise the solution of 4 or 5 (0.2 mmol, 1 equiv) in dry DMA (0.5 mL) by syringe. Then the mixture was heated at 60 °C until TLC showed the completion of the reaction. A saturated solution of NH₄Cl was added to quench the reaction and extracted with EtOAc for one time. The organic layer was washed with water for three times, and the combined aqueous layers were extracted with EtOAc for one time. The combined organic layers were washed with brine and dried over sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography to give corresponding products 3 or 6.

References:

Sun, Wanwan;Chen, Xiaobei;Hu, Ying;Geng, Huihui;Jiang, Yuanrui;Zhou, Yuxin;Zhu, Wenjing;Hu, Min;Hu, Haohua;Wang, Xingyi;Wang, Xinli;Zhang, Shilei;Hu, Yanwei [Tetrahedron Letters,2020,vol. 61,# 43,art. no. 152442] Location in patent:supporting information