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ChemicalBook CAS DataBase List Butyl lactate
138-22-7

Butyl lactate synthesis

13synthesis methods
n-Butyl lactate may be prepared via esterification of lactic acid and n-butyl alcohol.
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Yield:138-22-7 99.5%

Reaction Conditions:

stannous octoate;Nafion-H at 145; for 7 h;Product distribution / selectivity;

Steps:

2

EXAMPLE 2; [0024] The tubes of reactor I was charged with of the heterogeneous catalyst (Nafion-H). 200 g oligomers of lactic acid with the mean degree of polymerization (MDP) equal to 10, 65 g butanol, 60 g butyl lactate and 1.0g tin(ll) 2-ethylhexanoate are loaded into the vessel III. A resulting mixture circulated via (4) (approximate 86.7 g/h) through the heated reactor I (1450C) approximately within 7 hours.[0025] Then it begins continuous feeding butanol via (2) (approximate 10.4 g/h, 0.14 mol/h) into mixer IV and of lactic acid via (1) (approximate 11.7 g/h, 0.13 mol/h) into mixer VII. At the same time it begins continuous feeding mixture via (7) from the vessel III to column V according to the level of a liquid phase at the vessel III, withdrawal of condensate from the column V via (3) and from the column Il via (5). A heavy still bottoms of column V via (6) is recycled to the mixer VII. The mole ratio of butanol/oligomers (counting upon free lactic acid) in mixture fed to reactor I is equal to 0.16.[0026] The condensate of column 5 (approximate 19.8 g/h) has the following composition, %wt.: Butyl Lactate -95.5; Butanol - 3.0; Water -1.5. The yield of Butyl lactate is 99.5%.[0027] The condensate of column 2 (approximate 2.3 g/h) has the following composition %wt.: Lactic acid - 2; Butanol - 2; Butyl Lactate - 1 ; Water - 95.

References:

WO2008/98581,2008,A1 Location in patent:Page/Page column 5

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