ChemicalBook CAS DataBase List Butoprozine

Butoprozine synthesis

4synthesis methods

Product Name:Butoprozine
CAS Number:62228-20-0
Molecular formula:C28H38N2O2
Molecular Weight:434.61

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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Yield: 65%

Reaction Conditions:

Stage #1:(2-ethyl-indolizin-3-yl)-(4-hydroxy-phenyl)-methanone with potassium carbonate in N,N-dimethyl-formamide at 20; for 0.5 h;Sealed tube;
Stage #2:dibutyl-(3-chloro-propyl)-amine with potassium iodide in N,N-dimethyl-formamide at 150;

Steps:

Synthesis of Compound I, Butoprazine.
Compound IV (0.1 mmol), potassium carbonate (0.1 mmol) and N,N-dimethylformamide were added to a sealed reaction tube. The reaction was stirred at room temperature for half an hour, then potassium iodide (0.02 mmol) was added. N-(3-Chloropropyl)dibutylamine (0.15 mmol) was reacted at 150 °C. After the reaction is completed, saturated sodium hydrogencarbonate is added. After extracting with diethyl ether, the organic layer was combined and dried over anhydrous sodium sulfate. Separation by column chromatography (petroleum ether: ethyl acetate 10:1) obtaining a yellow liquid of Compound I, bupropopazine, the yield was 65%.

References:

Guizhou Chinese Academy Of Sciences Natural Result Chemical Emphasis Experiment Shi;Yang Yuzhu;Fang Youlai;Yang Shengxiang CN110283167, 2019, A Location in patent:Paragraph 0009