ChemicalBook CAS DataBase List 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline synthesis

10synthesis methods

Product Name:4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
CAS Number:190728-25-7
Molecular formula:C17H16N2O3
Molecular Weight:296.32

35654-56-9 Synthesis

35654-56-9
350 suppliers
$13.00/1g

123-30-8 Synthesis

123-30-8
615 suppliers
$10.00/5g

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

190728-25-7
203 suppliers
$11.00/250mg

Yield:190728-25-7 90%

Reaction Conditions:

with sodium t-butanolate in N,N-dimethyl acetamide at -5 - 110;

Steps:

1; 2 Example 1 Preparation of Compound (II)
The compound (I) (500 g, 2.23 μM), 4-aminophenol (345 g, 3.16 μM) are added to a reaction in the bottle, adding DMA (3 L), lowering the temperature to 0 °C -5 °C, drop which is in butanol sodium (430 g) of DMA (2 L) suspension, then completing, heating up to 100 °C -110 °C, thermal insulation reaction 4 - 5 hours. (TLC monitoring the reaction is complete, Rf value 0.4 (dichloromethane: methanol=20:1)). Lowering the temperature to -5 °C -0 °C, adding ice water (10 L), stirring crystallization 15 - 16 hours. Filtering, cake a little water to wash, for 50 °C drying by blowing 15 - 16 hours to obtain light yellow solid 595 g, yield 90%, HPLC purity 99.7%

References:

Jiangsu Haosen Pharmaceutical Group Co., Ltd.;Fan Xingbao;Zhang Liang;Chen Anfeng;Zhou Bingcheng CN109836382, 2019, A Location in patent:Paragraph 0072-0077

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190728-24-6 Synthesis