ChemicalBook CAS DataBase List Allyl isothiocyanate

Allyl isothiocyanate synthesis

9synthesis methods

Product Name:Allyl isothiocyanate
CAS Number:57-06-7
Molecular formula:C4H5NS
Molecular Weight:99.15

By distillation of sodium thiocyanate and allyl chloride

540-72-7 Synthesis

540-72-7
440 suppliers
$13.50/100G

107-05-1 Synthesis

107-05-1
411 suppliers
$16.80/100ML

57-06-7
6 suppliers
$14.00/25g

Yield:57-06-7 122 kg

Reaction Conditions:

with tetrabutylammomium bromide in dichloromethane at 60; for 15 h;Inert atmosphere;Large scale;Temperature;Solvent;

Steps:

1;2; 3; 4; 5; 6; 7; 8; 9; 10; 11 Synthesis of allyl isothiocyanate
(1) Synthesis of allyl isothiocyanatea. Put 100kg of sodium thiocyanate, 200Kg of 1,2-dichloroethane and 0.5kg of catalyst TBAB into the reaction kettle. The reaction system will slowly rise to 60, and then 93kg of allyl chloride will be added dropwise under nitrogen protection. , After the dripping ends, the insulation reaction will start.b. After 15 hours of incubation and reaction, sampling and testing is required to control the allyl chloride to be less than 1percent qualified. After the reaction is qualified, the system is cooled and filtered to obtain solid sodium chloride and filtrate. Sodium chloride is a by-product salt. (2) Allyl isothiocyanate distillationa. Solvent recovery: transfer the filtrate to the rectification kettle, heat it up, and recover the solvent. When the temperature of the reactor reaches 110°C, stop the solvent recovery, and recover a total of 180Kg of 1,2-dichloroethane. The recovered solvent can be reused Next response.b. Distillation: After recovering the solvent, the rectifying kettle will continue to rise to an external temperature of 120, reflux for 1 hour, control the reflux ratio of 2:1, the vacuum degree is 80mmHg, and take a sample to detect the instantaneous allyl isothiocyanate When the calibration content of allyl isothiocyanate is greater than 98percent, the finished product of allyl isothiocyanate is collected, and finally 122kg of finished product of allyl isothiocyanate with a content of 99.5percent is obtained.

References:

Jiangsu Zhongdan Chemical Co., Ltd.;Zhang Jiaqing;Wang Chunmin;Tang Jing;Ren Yunhua;Huang Zhenhong;Xu Zhuhua;Lu Hui CN111533672, 2020, A Location in patent:Paragraph 0038-0129

79-06-1 Synthesis